In its first full year of existence, the eLife Global South Committee for Open Science has worked to connect researchers and ...

Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Surrozen Inc, South San Francisco, United States Department of Interdisciplinary Oncology, Louisiana State University Health Science Center, New Orleans, United States Division of Gastroenterology and ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. The work by Fisher et al describes the role of novel RSPO ...

(A) Left panel. Schematic representation of the experimental workflow for 2D imaging of immunostained bone marrow cryosections from WT mice. Confocal imaging is performed on single ultrathin sections ...