eLife7h
eLife Global South Committee for Open Science: 2024 year in review
In its first full year of existence, the eLife Global South Committee for Open Science has worked to connect researchers and ...
eLife18h
Beta Cells: Opportunity makes a hub or a leader
Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.
eLife1d
Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model
Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...
eLife1d
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
eLife1d
Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9
In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...
eLife2d
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis
This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...
eLife3d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...
eLife6d
Impacts of Structural Properties of Myosin II Filaments on Force Generation
Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...
eLife6d
Orexin population activity precisely reflects net body movement across behavioral and metabolic states
This important study shows that the activity of hypothalamic hypocretin/orexin neurons (HONs) correlates with body movement over multiple behaviors. Sophisticated techniques and analyses showcase this ...
eLife6d
Mesoscale functional architecture in medial posterior parietal cortex
This important study measures the functional specialization of distinct subregions within the mouse posterior parietal cortex (PPC) using mesoscopic two-photon calcium imaging during visual ...
eLife6d
Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella
Department of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University, China; ...
eLife6d
A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids
This study presents an important finding on the molecular mechanism for transduction of environmentally induced polyphenism. The evidence supporting the claims of the author is solid. This paper would ...