George Lowe, the voice behind the irreverent animated superhero on Adult Swim's “Space Ghost Coast to Coast,” has died. He was 67. He died Sunday in Lakeland, Florida, two of his business representatives said.

Mr. Lowe’s booming voice and off-the-wall humor turned the animated “Space Ghost Coast to Coast” into a cult hit.

He was the secret weapon behind the cult-classic Cartoon Network series that reimagined the 1960s intergalactic superhero as temperamental talk show host.