An expected close contest features the Astros (-112 on the moneyline) against the Marlins (-107). Cal Quantrill (4-8) gets the start for the Miami Marlins, but there's been no pitching decision announced by the Houston Astros yet.

Find the latest odds, spread and score prediction for the Houston Astros vs. Miami Marlins MLB game on ESPN to be played on August 5, 2025 on ESPN.

Analyst Matt Snyder ranked the Marlins at No. 15, noting, “Since June 19, the Marlins have lost just one series and that was to the best team in baseball (and, later, the Marlins beat the Brewers in a series). And you know what? It isn't out of the question for them to make the playoffs. What a run.”

On Sunday, the Marlins swept the Yankees for the first time in franchise history, continuing their hot streak since June 13th.

The Astros sent nine men to the plate in a five-run inning that featured run-scoring hits by new arrivals Jesús Sánchez and Carlos Correa and a two-run double by Yainer Diaz. It backed a strong start by Jason Alexander and spurred Houston to an 8-2 win over the streaking Marlins at loanDepot park.

Sandy Alcantara gave up five runs on six hits on Monday, leading to an 8-2 Marlins loss to the Houston Astros at loanDepot park.