Several senior military commanders have been killed since Friday including Khamenei's main advisers from the Revolutionary Guards, Iran's elite military force: the Guards' overall commander Hossein Salami, its aerospace chief Amir Ali Hajizadeh who headed Iran's ballistic missile program and spymaster Mohammad Kazemi.

Israeli Prime Minister Benjamin Netanyahu told ABC News on Monday that targeting Iran's Supreme Leader, Ayatollah Ali Khamenei, would bring an end to the ongoing conflict between Israel and Iran, rather than escalate it.