Ageing and rejuvenation of tissue stem cells and their niches
WEBJul 20, 2022 · Stem cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on interactions with the niche. During ageing, stem cells decline in their regenerative...
Stem cell aging: mechanisms, regulators and therapeutic
WEBAging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity.
Stem-Cell Aging and Pathways to Precancer Evolution
WEBOct 4, 2023 · We examine the pathophysiological changes associated with stem-cell aging and inflammation and the contribution of those processes to the development of cancer.
Stem cell aging: mechanisms, regulators and therapeutic ... - Nature
WEBAug 6, 2014 · Stem cell aging is affected by many different cell-intrinsic and cell-extrinsic pathways, which often show cross-talk in the determination of stem cell function.
When stem cells grow old: phenotypes and mechanisms of stem cell aging ...
WEBJan 1, 2016 · In this Review, we discuss what is known about aging in some major stem cell populations: hematopoietic stem cells (HSCs), intestinal stem cells (ISCs), satellite cells of the skeletal muscle, neural stem cells (NSCs), skin …
How stem cells age and why this makes us grow old
WEBStem-cell ageing can result in some systems from the heritable accumulation of DNA damage, which can engage tumour-suppressor activation as the stem cell attempts to divide asymmetrically.
A stem cell aging framework, from mechanisms to interventions - Cell …
WEBOct 18, 2022 · In this review, we have systematically delineated unique features and mechanisms of tissue-specific stem cell aging and rejuvenation, providing a framework for understanding fundamental mechanisms that govern stem cell aging.
Stem cells and healthy aging | Science - AAAS
WEBDec 4, 2015 · Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic stem …
A stem cell aging framework, from mechanisms to interventions
WEBOct 18, 2022 · In this review, we elucidate aging-related features across different somatic stem cell types, with a specific focus on epigenetic changes, loss of protein homeostasis, and systemic influencing factors, including chronic inflammation, circadian rhythm dysregulation, and metabolic disorder.
Old human cells rejuvenated with stem cell technology
WEBMar 24, 2020 · Old human cells can become more youthful by coaxing them to briefly express proteins used to make induced pluripotent cells, Stanford researchers and their colleagues have found. The finding may have implications for aging research.