Diagnosis and Management of Limbal Stem Cell Deficiency
WEBFeb 1, 2014 · Limbal stem cell deficiency (LSCD) is a condition that affects the corneal epithelium and causes ocular pain and vision loss. Learn about the etiology, clinical presentation, diagnostic testing, and treatment options for partial and complete LSCD.
Limbal stem cell - Wikipedia
WEBLimbal stem cells, also known as corneal epithelial stem cells, are unipotent stem cells located in the basal epithelial layer of the corneal limbus. They form the border between the cornea and the sclera.
Limbal Stem Cells: Identity, Developmental Origin and …
WEBLimbal stem cells (LSC) represent a quiescent cell population with proliferative capacity residing in the basal epithelial layer of the limbus within a cellular niche.
Limbal Stem Cell Deficiency - EyeWiki
WEBLearn about the causes, pathophysiology, diagnosis, and treatment of limbal stem cell deficiency (LSCD), a condition that affects the corneal epithelium and the limbus. The limbus is the peripheral zone of the cornea that contains stem cells in pigmented crypts called the palisades of Vogt.
Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration
WEBJul 8, 2010 · Ocular burns may destroy the limbus, causing limbal stem-cell deficiency. We investigated the long-term clinical results of cell therapy in patients with burn-related corneal destruction ...
Limbal Stem Cell Transplantation: Clinical Results, Limits, and ...
WEBOct 11, 2018 · Limbal stem cell transplantation (LSCT) has been developed for the treatment of corneal conditions associated with functional and/or anatomical loss of corneal epithelial stem cells to restore the damaged corneal surface allowing subsequent visual …
Current perspectives of limbal‐derived stem cells and its …
WEBMay 5, 2021 · This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.
Comprehensive 3D epigenomic maps define limbal stem/progenitor cell ...
WEBMar 11, 2022 · Here, we generate a high-resolution Hi-C interaction map of human limbal stem/progenitor cells (LSCs) and show that chromatin multi-hierarchical organisation is coupled to gene expression.
Limbal Stem Cells in Review - PMC - National Center for …
WEBJul 29, 2008 · The concept of limbal stem cells has greatly improved our understanding of corneal epithelial proliferation, migration, and regeneration. This has also contributed directly to improved medical and surgical management of a wide range of ocular surface disorders. Many questions however remain.
Global Consensus on the Management of Limbal Stem Cell Deficiency
WEBPurpose: In recent decades, the medical and surgical treatment of limbal stem cell deficiency (LSCD) has evolved significantly through the incorporation of innovative pharmacological strategies, surgical techniques, bioengineering, and cell therapy.