Interleukin 22 - Wikipedia
WEBIL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. [7] IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins .
Interleukin-22: immunobiology and pathology - PMC - National …
WEBMar 3, 2015 · IL-22 receptor. The IL-22 receptor (IL-22R) is a Type 2 cytokine receptor and member of the IL-10 family of receptors along with the receptors for IL-10, IL-19, IL-20, IL-24, IL-26, IL-28 and IL-29 (Figure 1). It is composed of two heterodimeric subunits, IL-22R1 and IL-10R2 (2, 3, 11–13).
IL-22 as a target for therapeutic intervention: Current knowledge …
WEBSep 1, 2023 · The receptor for IL-22 is a etero-dimer of IL-22R1 and IL-10R2 is present on non-immune cells like fibroblasts and epithelial cells. The cytokine IL-22 binds to its receptor and forms IL-22-IL-22R1-IL-10R2 complex, which leads to activation of Janus kinases (JAK) and Tyrosine kinases (TYK).
The Roles of IL-22 and Its Receptor in the Regulation of …
WEBJan 11, 2022 · Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists of the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that IL-22Rα expression is restricted to non-hematopoietic cells in the skin, pancreas, intestine, liver, lung, and kidney.
IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
WEBNov 15, 2021 · The receptor for IL-22, a heterodimeric complex of IL-22R and IL-10Rβ, binds IL-22, activating signaling pathways that induce genes important for cellular proliferation, inhibition of apoptosis and tissue specific genes, that can include antimicrobial proteins and mucins.
IL-22 receptor signaling in Paneth cells is critical for their ... - Nature
WEBOct 15, 2020 · Interleukin-22 (IL-22) signaling in the intestines is critical for promoting tissue-protective functions.
Biological and Pathological Activities of Interleukin-22 - PMC
WEBIn this Review we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios, and discuss the potential to target IL-22 signaling to treat human diseases.
Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid ...
WEBFeb 21, 2024 · Here, the authors show in tissue-specific IL-22 receptor knockout mice a key role of intestinal epithelium-specific IL-22RA1 signaling in regulating intestinal metabolism and alleviating...
Therapeutic opportunities of the IL-22–IL-22R1 system
WEBDec 31, 2013 · Via its transmembrane receptor complex composed of IL-22 receptor 1 (IL-22R1) and IL-10R2, IL-22 mainly influences epithelial cells, hepatocytes, pancreatic acinar cells and related stem cells.
The tissue protective functions of interleukin-22 can be decoupled …
WEBApr 13, 2021 · Structure-based design of STAT3-biased IL-22 receptor agonists. •. Biased IL-22 variant 22-B3 elicits tissue-selective STAT3 activation in vivo. •. 22-B3 uncouples the tissue-protective and pro-inflammatory functions of IL-22. Summary.
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