Targeting interleukin-10 signalling for cancer immunotherapy, a ...
WEBMar 11, 2020 · Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing excessive immune responses to damage self. Temporal IL-10 signaling blockade enhances vaccine-induced tumor regression by CD8 + T cells.
IL-10R inhibition reprograms tumor-associated macrophages and …
WEBAug 30, 2024 · IL-10 is a key immunosuppressive cytokine that leads to recruitment and development of TAMs. In this study, we investigated the role of IL-10 in MM TAM development as well as the therapeutic...
The multifaceted nature of IL-10: regulation, role in immunological ...
WEBJun 8, 2023 · IL-10 is a master regulator of immunity during infection with viruses, bacteria, fungi, protozoa and other pathogens, playing a key, and often essential, role in limiting or terminating inflammation and in the consequent host protection.
Human IL-10 R alpha Antibody - R&D Systems
WEBIL-10 binds specifically and with high affinity to cell-surface receptors. Mouse and human cDNA clones encoding the ligand-binding IL-10 receptor (IL-10 R) have been isolated. The IL-10 R mRNA has been detected in all cell types that are known to respond to IL-10.
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The Generation of an Engineered Interleukin-10 Protein With …
WEBAug 11, 2020 · The anti-IL-10R antibody (clone: 1B1.3a) (Biolegend UK Ltd) was used to validate that the alteration in the luciferase response observed was dependent on the IL-10 receptor's engagement with IL-10. Unstimulated cells were used as a negative control.
Anti-IL10RA Antibodies | Invitrogen - Thermo Fisher Scientific
WEBOur IL10RA monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit, Rat and Goat. Find the IL10RA antibody that fits your needs. Choose from 1 of 37 IL10RA antibodies, which have been validated in experiments with 5 publications and 69 images featured in our data gallery.
IL-10RA antibody (13356-1-AP) | Proteintech - ptglab
WEB13356-1-AP targets IL-10RA in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment.
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Anti-IL-10RA antibody (AB225530) - Abcam
WEBAnti-IL-10RA antibody. Download. Rabbit Polyclonal IL-10RA antibody. Suitable for IHC-P and reacts with Human samples.
Anti-IL-10R antibody improves the therapeutic efficacy of …
WEBSep 1, 2009 · Interleukin 10 (IL-10) suppresses antigen presenting cell activation contributing to tumour-mediated immune suppression. In principle, combination of TL-asCpG and antibodies against IL-10 receptor (aIL-10R) could prolong immune system activation, leading to better therapeutic results.
Targeting of IL-10R on acute myeloid leukemia blasts with
WEBAug 14, 2021 · Introduction. Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. With conventional chemotherapy, the complete remission rate of AML is 60–80% for younger adults and...